The name was traditionally used in Christian sources throughout history and is still widely used as an international tourism concept to define a region of exceptional natural wonders, in particular characterized by fairy chimneys and a unique historical and cultural heritage. The term, as used in tourism, roughly corresponds to present-day Nevşehir Province.

In the time of Herodotus, the Cappadocians were reported as occupying the whole region from Mount Taurus to the vicinity of the Euxine (Black Sea). Cappadocia, in this sense, was bounded in the south by the chain of the Taurus Mountains that separate it from Cilicia, to the east by the upper Euphrates and the Armenian Highland, to the north by Pontus, and to the west by Lycaonia and eastern Galatia.

The earliest record of the name of Cappadocia dates from the late 6th century BC, when it appears in the trilingual inscriptions of two early Achaemenid kings, Darius I and Xerxes, as one of the countries (Old Persian dahyu-) of the Persian Empire. In these lists of countries, the Old Persian name is Katpatuka, clearly not a native Persian name. The Elamite and Akkadian language versions of the inscriptions contain a similar name from Akkadian katpa "side" (cf. Heb katef) and a chief or ancestor's name, Tuka.^[2]

Herodotus tells us that the name of the Cappadocians was applied to them by the Persians, while they were termed by the Greeks as "Syrians" or "White Syrians" (Leucosyri). One of the Cappadocian tribes he mentions is the Moschoi, associated by Flavius Josephus with the biblical figure Meshech, son of Japheth: "and the Mosocheni were founded by Mosoch; now they are Cappadocians". AotJ I:6. Also see Ketubot 13:11 in the Mishna.

Cappadocia is also mentioned in the biblical account given in the book of Acts 2:9. The Cappadocians were named as one group hearing the Gospel account from Galileans in their own language on the day of Pentecost shortly after the resurrection of Jesus Christ. Acts 2:5 seems to suggest that the Cappadocians in this account were "God-fearing Jews". See Acts of the Apostles.

Under the later kings of the Persian Empire, the Cappadocians were divided into two satrapies, or governments, with one comprising the central and inland portion, to which the name of Cappadocia continued to be applied by Greek geographers, while the other was called Pontus. This division had already come about before the time of Xenophon. As after the fall of the Persian government the two provinces continued to be separate, the distinction was perpetuated, and the name Cappadocia came to be restricted to the inland province (sometimes called Great Cappadocia), which alone will be the focus of this article.

The kingdom of Cappadocia was still in existence in the time of Strabo as a nominally independent state. Cilicia was the name given to the district in which Caesarea, the capital of the whole country, was situated. The only two cities of Cappadocia considered by Strabo to deserve that appellation were Caesarea (originally known as Mazaca) and Tyana, not far from the foot of the Taurus.

Cappadocia lies in eastern Anatolia, in the center of what is now Turkey. The relief consists of a high plateau over 1000m in altitude that is pierced by volcanic peaks, with Mount Erciyes (ancient Argaeus) near Kayseri (ancient Caesarea) being the tallest at 3916 m. The boundaries of historical Cappadocia are vague, particularly towards the west. To the south, the Taurus Mountains form the boundary with Cilicia and separate Cappadocia from the Mediterranean Sea. To the west, Cappadocia is bounded by the historical regions of Lycaonia to the southwest, and Galatia to the northwest. The Black Sea coastal ranges separate Cappadocia from Pontus and the Black Sea, while to the east Cappadocia is bounded by the upper Euphrates, before that river bends to the southeast to flow into Mesopotamia, and the Armenian Highland.^[3] This results in an area approximately 400 km (250 mi) east–west and 250 km (160 mi) north–south. Due to its inland location and high altitude, Cappadocia has a markedly continental climate, with hot dry summers and cold snowy winters.^[4] Rainfall is sparse and the region is largely semi-arid.

Cappadocia was known as Hatti in the late Bronze Age, and was the homeland of the Hittite power centred at Hattusa. After the fall of the Hittite Empire, with the decline of the Syro-Cappadocians (Mushki) after their defeat by the Lydian king Croesus in the 6th century, Cappadocia was ruled by a sort of feudal aristocracy, dwelling in strong castles and keeping the peasants in a servile condition, which later made them apt for foreign slavery. It was included in the third Persian satrapy in the division established by Darius, but continued to be governed by rulers of its own, none apparently supreme over the whole country and all more or less tributaries of the Great King.

After bringing the Persian Empire to an end, Alexander the Great tried to rule the area through one of his military commanders. But Ariarathes, a Persian aristocrat, somehow became king of the Cappadocians. Ariarthes I (332—322 BC) was a successful ruler, and he extended the borders of the Cappadocian Kingdom as far as to the Black Sea. The kingdom of Cappadocia lived in peace until the death of Alexander. The previous empire was then divided into many parts, and Cappadocia fell to Eumenes. His claims were made good in 322 BC by the regent Perdiccas, who crucified Ariarathes; but in the dissensions which brought about Eumenes's death, the son of Ariarathes recovered his inheritance and left it to a line of successors, who mostly bore the name of the founder of the dynasty.

Under Ariarathes IV, Cappadocia came into relations with Rome, first as a foe espousing the cause of Antiochus the Great, then as an ally against Perseus of Macedon. The kings henceforward threw in their lot with the Republic as against the Seleucids, to whom they had been from time to time tributary. Ariarathes V marched with the Roman proconsul Publius Licinius Crassus Dives Mucianus against Aristonicus, a claimant to the throne of Pergamon, and their forces were annihilated (130 BC). The imbroglio which followed his death ultimately led to interference by the rising power of Pontus and the intrigues and wars which ended in the failure of the dynasty.

The Cappadocians, supported by Rome against Mithridates VI of Pontus, elected a native lord, Ariobarzanes, to succeed (93 BC); but in the same year Armenian troops under Tigranes the Great (Tigran) entered Cappadocia, dethroned king Ariobarzanes and crowned Gordios as the new client-king of Cappadocia, thus creating a buffer zone against the encroaching Romans. It was not until Rome had deposed the Pontic and Armenian kings that the rule of Ariobarzanes was established (63 BC). In the civil wars Cappadocia was now for Pompey, now for Caesar, now for Antony, now against him. The Ariobarzanes dynasty came to an end and a certain Archelaus reigned in its stead, by favour first of Antony and then of Octavian, and maintained tributary independence until AD 17, when the emperor Tiberius, on Archelaus' death in disgrace, reduced Cappadocia at last to a Roman province. Much later it was a region of the Byzantine Empire.

Cappadocia contains several underground cities (see Kaymaklı Underground City), largely used by early Christians as hiding places before they became an accepted religion. The Cappadocian Fathers of the 4th century were integral to much of early Christian philosophy. It also produced, among other people, another Patriarch of Constantinople, John of Cappadocia, who held office 517—520. For most of the Byzantine era it remained relatively undisturbed by the conflicts in the area with the Sassanid Empire, but was a vital frontier zone later against the Muslim conquests. Cappadocia formed part of the Armeniac Theme and later of the themes of Charsianon and Cappadocia.

Cappadocia shared an always changing relation with the neighbouring Armenia, by that time a region of the Empire. The Arab historian Abu Al Faraj purports the following about Armenian settlers in Sivas, during the 10th century: "Sivas, in Cappadocia, was dominated by the Armenians and their numbers became so many that they became vital members of the imperial armies. These Armenians were used as watch-posts in strong fortresses, taken from the Arabs. They distinguished themselves as experienced infantry soldiers in the imperial army and were constantly fighting with outstanding courage and success by the side of the Romans in other words Byzantine".^[6] As a result of the Byzantine military campaigns and the Seljuk invasion of Armenia, the Armenians spread into Cappadocia and eastward from Cilicia into the mountainous areas of northern Syria and Mesopotamia, and the Armenian Kingdom of Cilicia was eventually formed. This immigration was increased further after the decline of the local imperial power and the establishment of the Crusader States following the Fourth Crusade. To the crusaders, Cappadocia was "terra Hermeniorum," the land of the Armenians, due to the large number of Armenians settled there.^[7]

Following the Battle of Manzikert in 1071, various Turkish clans under the leadership of the Seljuks began settling in Anatolia. With the rise of Turkish power in Anatolia, Cappadocia slowly became a tributary to the Turkish states that were established to the east and to the west, and some of the population converted to Islam. By the end of the early 12th century, Anatolian Seljuks had established their sole dominance over the region. With the decline and the fall of the Konya-based Seljuks in the second half of the 13th century, they were gradually replaced by the Karaman-based Beylik of Karamanoğlu, who themselves were gradually succeeded by the Ottoman Empire over the course of the 15th century. Cappadocia remained part of the Ottoman Empire for the centuries to come, and remains now part of the modern state of Turkey. A fundamental change occurred in between when a new urban center, Nevşehir, was founded in the early 18th century by a grand vizier who was a native of the locality (Nevşehirli Damat İbrahim Pasha), to serve as regional capital, a role the city continues to assume to this day.

In the meantime many former Cappadocians had shifted to a Turkish dialect (written in Greek alphabet, Karamanlıca), and where the Greek language was maintained (Sille, villages near Kayseri, Pharasa town and other nearby villages), it became heavily influenced by the surrounding Turkish. This dialect of Greek is known as Cappadocian Greek. Following the 1923 population exchange between Greece and Turkey, the language is now only spoken by a handful of the former population's descendants in modern Greece.

The area is a famous and popular tourist destination, as it has many areas with unique geological, historic and cultural features.

The region is located southwest of the major city Kayseri, which has airline and railroad (railway) service to Ankara and Istanbul.

The Cappadocia region is largely underlain by sedimentary rocks formed in lakes and streams, and ignimbrite deposits erupted from ancient volcanoes approximately 9 to 3 million years ago, during the late Miocene to Pliocene epochs. The rocks of Cappadocia near Göreme eroded into hundreds of spectacular pillars and minaret-like forms. The volcanic deposits are soft rocks that the people of the villages at the heart of the Cappadocia Region carved out to form houses, churches and monasteries. Göreme became a monastic center between 300—1200 AD.

The first period of settlement in Göreme goes back to the Roman period. The Yusuf Koç, Ortahane, Durmus Kadir and Bezirhane churches in Göreme, houses and churches carved into rocks in the Uzundere, Bağıldere and Zemi Valleys are all carriers of history that we can see today. The Göreme Open Air Museum is the most visited site of the monastic communities in Cappadocia (see Churches of Göreme, Turkey) and is one of the most famous sites in central Turkey. The complex contains more than 30 rock-carved churches and chapels, some of them have superb frescoes inside, dating from the 9th to the 11th centuries.

In 1975 a study of three small villages in central Cappadocia—Tuzköy, Karain and Sarıhıdır—found that mesothelioma was causing 50 % of all deaths. Initially, this was attributed to erionite, a zeolite mineral with similar properties to asbestos, but detailed epidemiological investigation demonstrated that the substance causes the disease mostly in families with a genetic predisposition to mineral fiber carcinogenesis. The studies are being extended to other parts of the region.